Computational Lipidomics of the Neuronal Plasma Membrane.

ABSTRACT: Membrane lipid composition varies greatly within submembrane compartments, different organelle membranes, and also between cells of different cell stage, cell and tissue types, and organisms. Environmental factors (such as diet) also influence membrane composition. The membrane lipid composition is tightly regulated by the cell, maintaining a homeostasis that, if disrupted, can impair cell function and lead to disease. This is especially pronounced in the brain, where defects in lipid regulation are linked to various neurological diseases. The tightly regulated diversity raises questions on how complex changes in composition affect overall bilayer properties, dynamics, and lipid organization of cellular membranes. Here, we utilize recent advances in computational power and molecular dynami

SUBMITTER: Ingolfsson HI 

PROVIDER: S-EPMC5700369 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature