Global Transcriptome Analysis of Aedes aegypti Mosquitoes in Response to Zika Virus Infection.

ABSTRACT: Zika virus (ZIKV) of the Flaviviridae family is a recently emerged mosquito-borne virus that has been implicated in the surge of the number of microcephaly instances in South America. The recent rapid spread of the virus led to its declaration as a global health emergency by the World Health Organization. The virus is transmitted mainly by the mosquito Aedes aegypti, which is also the vector of dengue virus; however, little is known about the interactions of the virus with the mosquito vector. In this study, we investigated the transcriptome profiles of whole A. aegypti mosquitoes in response to ZIKV infection at 2, 7, and 14 days postinfection using transcriptome sequencing. Results showed changes in the abundance of a large number of transcripts at each time point fo

SUBMITTER: Etebari K 

PROVIDER: S-EPMC5700376 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature