High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery.

ABSTRACT:

Objectives

To examine associations between the inflammatory marker C-reactive protein (CRP) measured preoperatively and on postoperative day 2 (POD2) and delirium incidence, duration, and feature severity.

Design

Prospective cohort study.

Setting

Two academic medical centers.

Participants

Adults aged 70 and older undergoing major noncardiac surgery (N = 560).

Measurements

Plasma CRP was measured using enzyme-linked immunosorbent assay. Delirium was assessed from Confusion Assessment Method (CAM) interviews and chart review. Delirium duration was measured according to number of hospital days with delirium. Delirium feature severity was defined as the sum of CAM-Severity (CAM-S) scores on all postoperative hospital days. Generalized linear models were used

SUBMITTER: Vasunilashorn SM 

PROVIDER: S-EPMC5700456 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature