Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study.

ABSTRACT:

Objectives

To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

Design

A prospective cohort study.

Setting

University medical centre.

Participants

Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants.

Measurements

The inflammatory marker levels in plasma and cognitive function were measured.

Results

Twenty (39.2%, 20/51) patients developed POCD at 1 w after CRS-HIPEC. The patients with POCD had higher serum interleukin 1β (IL-1β), serum amyloid A (SAA), S100 calcium-binding protein β (S-100β), and high mobility group box-1 pro

SUBMITTER: Yu H 

PROVIDER: S-EPMC5700480 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature