Detection of the LINE-1 retrotransposon RNA-binding protein ORF1p in different anatomical regions of the human brain.

ABSTRACT:

Background

Recent reports indicate that retrotransposons - a type of mobile DNA - can contribute to neuronal genetic diversity in mammals. Retrotransposons are genetic elements that mobilize via an RNA intermediate by a "copy-and-paste" mechanism termed retrotransposition. Long Interspersed Element-1 (LINE-1 or L1) is the only active autonomous retrotransposon in humans and its activity is responsible for ~ 30% of genomic mass. Historically, L1 retrotransposition was thought to be restricted to the germline; however, new data indicate L1 s are active in somatic tissue with certain regions of the brain being highly permissive. The functional implications of L1 insertional activity in the brain and how host cells regulate it are incomplete. While deep sequencing and qPCR analysis hav

SUBMITTER: Sur D 

PROVIDER: S-EPMC5700708 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature