MsaABCR operon is involved in persister cell formation in Staphylococcus aureus.

ABSTRACT:

Background

Persister cells comprise a phenotypic variant that shows extreme antibiotic tolerance resulting in treatment failures of bacterial infections. While this phenomenon has posed a great threat in public health, mechanisms underlying their formation in Staphylococcus aureus remain largely unknown. Increasing evidences of the presence of persister cells in recalcitrant infections underscores the great urgency to unravel the mechanism by which these cells develop. Previously, we characterized msaABCR operon that plays roles in regulation of virulence, biofilm development and antibiotic resistance. We also characterized the function of MsaB protein and showed that MsaB is a putative transcription factor that binds target DNA in response to nutrients availability.

Results

SUBMITTER: Sahukhal GS 

PROVIDER: S-EPMC5700755 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature