Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis.

ABSTRACT:

Background

HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial global disease burden and are epidemiologically correlated. Two previous systematic reviews of the association between HSV-2 and HIV found evidence that HSV-2 infection increases the risk of HIV acquisition, but these reviews are now more than a decade old.

Methods

For this systematic review and meta-analysis, we searched PubMed, MEDLINE, and Embase (from Jan 1, 2003, to May 25, 2017) to identify studies investigating the risk of HIV acquisition after exposure to HSV-2 infection, either at baseline (prevalent HSV-2 infection) or during follow-up (incident HSV-2 infection). Studies were included if they were a cohort study, controlled trial, or case-control study (including case-control stud

SUBMITTER: Looker KJ 

PROVIDER: S-EPMC5700807 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature