⁸⁹Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer.

ABSTRACT:

Purpose

Nivolumab is a human monoclonal antibody specific for programmed cell death-1 (PD-1), a negative regulator of T-cell activation and response. Acting as an immune checkpoint inhibitor, nivolumab binds to PD-1 expressed on the surface of many immune cells and prevents ligation by its natural ligands. Nivolumab is only effective in a subset of patients, and there is limited evidence supporting its use for diagnostic, monitoring, or stratification purposes.

Methods

⁸⁹Zr-Df-nivolumab was synthesized to map the biodistribution of PD-1-expressing tumor infiltrating T-cells in vivo using a humanized murine model of lung cancer. The tracer was developed by radiolabeling the antibody with the positron emitter zirconium-89 (⁸⁹Zr). Imaging results were vali

SUBMITTER: England CG 

PROVIDER: S-EPMC5700850 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature