Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells.

ABSTRACT: Growing evidence suggests that agonists of glucagon-like peptide (GLP-1) receptor exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration, and, recently, a pilot clinical trial of Liraglutide in Alzheimer's disease patients showed improvements in cerebral glucose consumption that signifies disease progression. However, the exact underlying mechanism of action remains unclear. Chronic endoplasmic reticulum (ER) stress has recently emerged as a mechanism for neuronal injury, rendering it a potent therapeutic target for acute and chronic neurodegenerative disorders. Here, we investigate the neuroprotective effects of Liraglutide along with the signalling network against prolong ER stress and autophagy impairments induced by the non-com

SUBMITTER: Panagaki T 

PROVIDER: S-EPMC5700973 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature