Ontology highlight
ABSTRACT:
SUBMITTER: Temimi AHKA
PROVIDER: S-EPMC5700997 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20171123 1
Histone lysine methyltransferases (KMTs) represent an important class of epigenetic enzymes that play essential roles in regulation of gene expression in humans. Members of the KMT family catalyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone tails and core histones. Here we report combined MALDI-TOF MS experiments, NMR analyses and quantum mechanical/molecular dynamics studies on human KMT-catalyzed methylation of the most related shorter and lon ...[more]