Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA_1c.

ABSTRACT: Glycated haemoglobin (HbA_1c) is widely used as a biomarker for the diagnosis of diabetes, for population-level screening, and for monitoring the glycaemic status during medical treatment. Although the heritability of HbA_1c has been estimated at ~55-75%, a much smaller proportion of phenotypic variance is explained by the HbA_1c-associated variants identified so far. To search for novel loci influencing the HbA_1c levels, we conducted a genome-wide meta-analysis of 2 non-diabetic Japanese populations (n = 7,704 subjects in total). We identified 2 novel loci that achieved genome-wide significance: TMC6-TMC8 (P = 5.3 × 10^-20) and SIX3-SIX2 (P = 8.6 × 10^-9). Data from the largest-scale European GWAS conducted for HbA_1c

SUBMITTER: Hachiya T 

PROVIDER: S-EPMC5701039 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature