Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold.

ABSTRACT: Gold-catalyzed intermolecular alkyne oxidation by an N-O bond oxidant has proven to be a powerful method in organic synthesis during the past decade, because this approach would enable readily available alkynes as precursors in generating α-oxo gold carbenes. Among those, gold-catalyzed oxidative cyclization of dialkynes has received particular attention as this chemistry offers great potential to build structurally complex cyclic molecules. However, these alkyne oxidations have been mostly limited to noble metal catalysts, and, to our knowledge, non-noble metal-catalyzed reactions such as diyne oxidations have not been reported. Herein, we disclose a copper-catalyzed oxidative diyne cyclization, allowing the facile synthesis of a wide range of valuable pyrrolo[3,4-c]quinolin-1-ones. Inter

SUBMITTER: Shen WB 

PROVIDER: S-EPMC5701061 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature