Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy.

ABSTRACT: The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enh

SUBMITTER: Chen W 

PROVIDER: S-EPMC5701150 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature