Regulation of mating type switching by the mating type genes and RME1 in Ogataea polymorpha.

ABSTRACT: Saccharomyces cerevisiae and its closely related yeasts undergo mating type switching by replacing DNA sequences at the active mating type locus (MAT) with one of two silent mating type cassettes. Recently, a novel mode of mating type switching was reported in methylotrophic yeast, including Ogataea polymorpha, which utilizes chromosomal recombination between inverted-repeat sequences flanking two MAT loci. The inversion is highly regulated and occurs only when two requirements are met: haploidy and nutritional starvation. However, links between this information and the mechanism associated with mating type switching are not understood. Here we investigated the roles of transcription factors involved in yeast sexual development, such as mating type genes and the conserved zinc finger prote

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC5701183 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature