In silico design of a Zika virus non-structural protein 5 aiming vaccine protection against zika and dengue in different human populations.

ABSTRACT:

Background

The arboviruses Zika virus (ZIKV) and Dengue virus (DENV) have important epidemiological impact in Brazil and other tropical regions of the world. Recently, it was shown that previous humoral immunity to DENV enhances ZIKV replication in vitro, which may lead to more severe forms of the disease. Thus, traditional approaches of vaccine development aiming to control viral infection through neutralizing antibodies may induce cross-reactive enhancing antibodies. In contrast, cellular immune response was shown to be capable of controlling DENV infection independently of antibodies. The aim of the present study was to design a flavivirus NS5 protein capable of inducing a cellular immune response against DENV and ZIKV.

Methods

A consensus sequence of ZIKV NS5 protein was

SUBMITTER: Dos Santos Franco L 

PROVIDER: S-EPMC5701345 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature