Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer.

ABSTRACT:

Background

Epigenetic alterations are strongly associated with the development of cancer. The aim of this study was to identify epigenetic pattern in squamous cell lung cancer (LUSC) on a genome-wide scale.

Results

Here we performed DNA methylation profiling on 24 LUSC and paired non-tumor lung (NTL) tissues by Illumina Human Methylation 450 K BeadArrays, and identified 5214 differentially methylated probes. By integrating DNA methylation and mRNA expression data, 449 aberrantly methylated genes accompanied with altered expression were identified. Ingenuity Pathway analysis highlighted these genes which were closely related to the carcinogenesis of LUSC, such as ERK family, NFKB signaling pathway, Hedgehog signaling pathway, providing new clues for understanding the molecula

SUBMITTER: Shi YX 

PROVIDER: S-EPMC5701423 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature