Vitamin D deficiency in critically ill children: a systematic review and meta-analysis.

ABSTRACT:

Background

Vitamin D deficiency (VDD) has been hypothesized not only to be common but also to represent a potentially modifiable risk factor for greater illness severity and clinical outcome during critical illness. The objective of this systematic review was to determine the frequency of VDD in pediatric critical illness and its association with clinical outcomes.

Methods

MEDLINE, Embase, and CENTRAL were searched through December 12, 2016, with no date or language restrictions. The primary objective was to estimate the prevalence of VDD in the pediatric intensive care unit (PICU) and compare vitamin D status with healthy control populations. Secondary objectives were to evaluate whether VDD is associated with mortality, increased illness severity, PICU interventions, and p

SUBMITTER: McNally JD 

PROVIDER: S-EPMC5701429 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature