Image-based quantitative analysis of tear film lipid layer thickness for meibomian gland evaluation.

ABSTRACT:

Background

Dry eye syndrome is one of the most common ocular diseases, and meibomian gland dysfunction (MGD) is the leading cause of evaporative dry eye syndrome. When the tear film lipid layer becomes thin due to obstructive or hyposecretory meibomian gland dysfunction, the excessive evaporation of the aqueous layer can occur, and this causes evaporative dry eye syndrome. Thus, measuring the lipid layer thickness (LLT) is essential for accurate diagnosis and proper treatment of evaporative dry eye syndrome.

Methods

We used a white LED panel with a slit lamp microscope to obtain videos of the lipid layer interference patterns on the cornea. To quantitatively analyze the LLT from interference colors, we developed a novel algorithm that can automatically perform the following

SUBMITTER: Hwang H 

PROVIDER: S-EPMC5701431 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature