Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates.

ABSTRACT:

Background

Siglecs-11 and -16 are members of the sialic acid recognizing Ig-like lectin family, and expressed in same cells. Siglec-11 functions as an inhibitory receptor, whereas Siglec-16 exhibits activating properties. In humans, SIGLEC11 and SIGLEC16 gene sequences are extremely similar in the region encoding the extracellular domain due to gene conversions. Human SIGLEC11 was converted by the nonfunctional SIGLEC16P allele, and the converted SIGLEC11 allele became fixed in humans, possibly because it provides novel neuroprotective functions in brain microglia. However, the detailed evolutionary history of SIGLEC11 and SIGLEC16 in other primates remains unclear.

Results

We analyzed SIGLEC11 and SIGLEC16 gene sequences of multiple primate species, and examined glycan bind

SUBMITTER: Hayakawa T 

PROVIDER: S-EPMC5701461 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature