Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma.

ABSTRACT:

Background

Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hypermethylation and loss of the tumor suppressor Retinoic acid receptor responder 1 (RARRES1) were shown to contribute to cancer progression. Our study investigated the epigenetic and transcriptional regulation of RARRES1 in healthy human placenta in comparison to choriocarcinoma cell lines and cases.

Methods

Three choriocarcinoma cell lines (Jeg-3, JAR and BeWo) were treated with three different retinoic acid derivates (Am580, Tazarotene and all-trans retinoic

SUBMITTER: Huebner H 

PROVIDER: S-EPMC5701501 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature