Histological Grading of Hepatocellular Carcinoma-A Systematic Review of Literature.

ABSTRACT:

Background

Histological grading typically reflects the biological behavior of solid tumors, thus providing valuable prognostic information. This is also expected in hepatocellular carcinoma (HCC), although limited access to biopsy samples and a lack of standardization might hinder its full predictive value in this cancer.

Objectives

In order to better understand the current practices of histological grading in HCC, we examined the latest publications addressing its impact on the outcome of patients following surgical treatment.

Methods

We searched the PubMed (MEDLINE) database under the headings "hepatocellular carcinoma," "grade OR grading," and "prognosis." Qualitative and quantitative assessment of publications was performed according to the reference they used to

SUBMITTER: Martins-Filho SN 

PROVIDER: S-EPMC5701623 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature