High birth prevalence of sickle cell disease in Northwestern Tanzania.

ABSTRACT:

Background

Worldwide, hemoglobinopathies affect millions of children. Identification of hemoglobin disorders in most sub-Saharan African countries is delayed until clinical signs of the disease are present. Limited studies have been conducted to understand their prevalence and clinical presentation among newborns in resource-limited settings.

Methodology

This was a prospective cohort study. Newborns (aged 0-7 days) at two hospitals in Northwestern Tanzania were enrolled and followed prospectively for 6 months. Clinical and laboratory information were collected at baseline. Participants were screened for hemoglobinopathies using high-performance liquid chromatography. Clinical and laboratory follow-up was performed at 3 and 6 months for those with hemoglobinopathies as well a

SUBMITTER: Ambrose EE 

PROVIDER: S-EPMC5701733 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature