Effects of 3-year denosumab treatment on hip structure in Japanese postmenopausal women and men with osteoporosis.

ABSTRACT: Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients. However, there have been no data showing actions on Japanese bone architecture. Here we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for 3 years. Compared to placebo, denosumab significantly increased bone mineral density, cortical thickness and cross sectional area in all of the three analyzed areas: the narrow neck, intertrochanter and femoral shaft. The subsequent derived mechanical parameters, cross-sectional moment of inertia, section modulus and buckling ratio, were also improved by denosumab. In addition, the improvement of these parameters was also observed in the patients that

SUBMITTER: Sone T 

PROVIDER: S-EPMC5701790 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature