Somatic Mutations and Ancestry Markers in Hispanic Lung Cancer Patients.

ABSTRACT:

Introduction

To address the lack of genomic data from Hispanic/Latino (H/L) patients with lung cancer, the Latino Lung Cancer Registry was established to collect patient data and biospecimens from H/L patients.

Methods

This retrospective observational study examined lung cancer tumor samples from 163 H/L patients, and tumor-derived DNA was subjected to targeted-exome sequencing (>1000 genes, including EGFR, KRAS, serine/threonine kinase 11 gene [STK11], and tumor protein p53 gene [TP53]) and ancestry analysis. Mutation frequencies in this H/L cohort were compared with those in a similar cohort of non-Hispanic white (NHW) patients and correlated with ancestry, sex, smoking status, and tumor histologic type.

Results

Of the adenocarcinomas in the H/L cohort (n = 120), 31

SUBMITTER: Gimbrone NT 

PROVIDER: S-EPMC5701827 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature