Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.

ABSTRACT: Associations of MC1R with BRAF mutations in melanoma have been inconsistent between studies. We sought to determine for 1,227 participants in the international population-based Genes, Environment, and Melanoma (GEM) study whether MC1R and phenotypes were associated with melanoma BRAF/NRAS subtypes. We used logistic regression adjusted by age, sex, and study design features and examined effect modifications. BRAF⁺ were associated with younger age, blond/light brown hair, increased nevi, and less freckling, and NRAS⁺ with older age relative to the wild type (BRAF^-/NRAS^-) melanomas (all P < 0.05). Comparing specific BRAF subtypes to the wild type, BRAF V600E was associated with younger age, blond/light brown hair, and increased nevi and V600K with i

SUBMITTER: Thomas NE 

PROVIDER: S-EPMC5701875 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature