Consumption of Diet Containing Free Amino Acids Exacerbates Colitis in Mice.

ABSTRACT: Dietary proteins can influence the maturation of the immune system, particularly the gut-associated lymphoid tissue, when consumed from weaning to adulthood. Moreover, replacement of dietary proteins by amino acids at weaning has been shown to impair the generation of regulatory T cells in the gut as well as immune activities such as protective response to infection, induction of oral and nasal tolerance as well as allergic responses. Polymeric and elemental diets are used in the clinical practice, but the specific role of intact proteins and free amino acids during the intestinal inflammation are not known. It is plausible that these two dietary nitrogen sources would yield distinct immunological outcomes since proteins are recognized by the immune system as antigens and amino acids do no

SUBMITTER: Souza AL 

PROVIDER: S-EPMC5701921 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature