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β1-Adrenergic Receptor Contains Multiple IA^k and IE^k Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice.

ABSTRACT: Myocarditis/dilated cardiomyopathy (DCM) patients can develop autoantibodies to various cardiac antigens and one major antigen is β1-adrenergic receptor (β₁AR). Previous reports indicate that animals immunized with a β₁AR fragment encompassing, 197-222 amino acids for a prolonged period can develop DCM by producing autoantibodies, but existence of T cell epitopes, if any, were unknown. Using A/J mice that are highly susceptible to lymphocytic myocarditis, we have identified β₁AR 171-190, β₁AR 181-200, and β₁AR 211-230 as the major T cell epitopes that bind major histocompatibility complex class II/IA^k or IE^k alleles, and by creating IA^k and IE^k dextramers, we demonstrate that the CD4 T cell r

SUBMITTER: Basavalingappa RH

PROVIDER: S-EPMC5701947 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

β1-Adrenergic Receptor Contains Multiple IA^k and IE^k Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

β1-Adrenergic Receptor Contains Multiple IAk and IEk Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

β1-Adrenergic Receptor Contains Multiple IA^k and IE^k Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice.