Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis.

ABSTRACT:

Objective

To assess the relative effects of individual testosterone products among hypogonadal men.

Design

Systematic review and network meta-analysis.

Methods

We searched MEDLINE, Embase, Cochrane CENTRAL, and grey literature (25 May 2017) for randomised-controlled trials (RCTs) and non-randomised studies (NRS) that involved hypogonadal men given testosterone replacement therapy (TRT) for ≥3 months. Comparators were placebo, another TRT, or the same product at a different dose. Outcomes were quality of life, depression, libido, erectile function, activities of daily living and testosterone levels, as well as cardiovascular death, myocardial infarction, stroke, prostate cancer, heart disease, diabetes, serious adverse events, withdrawals due to adverse events and eryt

SUBMITTER: Elliott J 

PROVIDER: S-EPMC5701987 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature