Comprehensive analysis of vitreous specimens for uveitis classification: a prospective multicentre observational study.

ABSTRACT:

Purpose

To determine the clinical relevance of vitreous biomarkers in patients with uveitis.

Design

Multicentre, prospective, observational study.

Setting

Uveitis outpatient clinics of two academic medical centres in Japan.

Patient population

This study included 234 eyes of 191 patients with various uveitis aetiologies: definitive sarcoidosis (61 eyes of 46 patients), suspected sarcoidosis (60 eyes of 45 patients), intraocular tumour (34 eyes of 27 patients), viral infection (20 eyes of 18 patients), non-sarcoidosis (16 eyes of 16 patients) and unknown aetiology (43 eyes of 39 patients).

Observation procedure

Vitreous samples (taken by pars planta vitrectomy) were analysed with flow cytometry, cytology and multiplex PCR analysis.

Main outcome measures

SUBMITTER: Maruyama K 

PROVIDER: S-EPMC5701993 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature