Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study.

ABSTRACT:

Objective

To determine the frequency of biochemical monitoring after initiation of aldosterone antagonists(AA) in patients also using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB).

Setting

UK primary care.

Participants

ACEI/ARB users who initiated AA between 2004 and 2014.

Outcomes

We calculated the proportions with: (1) biochemical monitoring ≤2 weeks post initiation of AA, (2) adverse biochemical values ≤2 months (potassium ≥6 mmol/L, creatinine ≥220 µmol/L and ≥30% increase in creatinine from baseline) and (3) discontinuers of AA in those with an adverse biochemical value. We used logistic regression to study patient characteristics associated with monitoring and adverse biochemical values.

Results

In 10 546 initiat

SUBMITTER: Sinnott SJ 

PROVIDER: S-EPMC5701996 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature