The chronically inflamed central nervous system provides niches for long-lived plasma cells.

ABSTRACT: Although oligoclonal bands in the cerebrospinal fluid have been a hallmark of multiple sclerosis diagnosis for over three decades, the role of antibody-secreting cells in multiple sclerosis remains unclear. T and B cells are critical for multiple sclerosis pathogenesis, but increasing evidence suggests that plasma cells also contribute, through secretion of autoantibodies. Long-lived plasma cells are known to drive various chronic inflammatory conditions as e.g. systemic lupus erythematosus, however, to what extent they are present in autoimmune central nervous system inflammation has not yet been investigated. In brain biopsies from multiple sclerosis patients and other neurological diseases, we could detect non-proliferating plasma cells (CD138⁺Ki67^-) in the parench

SUBMITTER: Pollok K 

PROVIDER: S-EPMC5702095 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature