A multiscale modeling study of particle size effects on the tissue penetration efficacy of drug-delivery nanoparticles.

ABSTRACT:

Background

Particle size is a key parameter for drug-delivery nanoparticle design. It is believed that the size of a nanoparticle may have important effects on its ability to overcome the transport barriers in biological tissues. Nonetheless, such effects remain poorly understood. Using a multiscale model, this work investigates particle size effects on the tissue distribution and penetration efficacy of drug-delivery nanoparticles.

Results

We have developed a multiscale spatiotemporal model of nanoparticle transport in biological tissues. The model implements a time-adaptive Brownian Dynamics algorithm that links microscale particle-cell interactions and adhesion dynamics to tissue-scale particle dispersion and penetration. The model accounts for the advection, diffusion, a

SUBMITTER: Islam MA 

PROVIDER: S-EPMC5702122 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature