Optimization of the prescription isodose line for Gamma Knife radiosurgery using the shot within shot technique.

ABSTRACT:

Background

This work explores how the choice of prescription isodose line (IDL) affects the dose gradient, target coverage, and treatment time for Gamma Knife radiosurgery when a smaller shot is encompassed within a larger shot at the same stereotactic coordinates (shot within shot technique).

Methods

Beam profiles for the 4, 8, and 16 mm collimator settings were extracted from the treatment planning system and characterized using Gaussian fits. The characterized data were used to create over 10,000 shot within shot configurations by systematically changing collimator weighting and choice of prescription IDL. Each configuration was quantified in terms of the dose gradient, target coverage, and beam-on time. By analyzing these configurations, it was found that there are regio

SUBMITTER: Johnson PB 

PROVIDER: S-EPMC5702131 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature