Sugar Lego: gene composition of bacterial carbohydrate metabolism genomic loci.

ABSTRACT:

Background

Bacterial carbohydrate metabolism is extremely diverse, since carbohydrates serve as a major energy source and are involved in a variety of cellular processes. Bacterial genes belonging to same metabolic pathway are often co-localized in the chromosome, but it is not a strict rule. Gene co-localization in linked to co-evolution and co-regulation. This study focuses on a large-scale analysis of bacterial genomic loci related to the carbohydrate metabolism.

Results

We demonstrate that only 53% of 148,000 studied genes from over six hundred bacterial genomes are co-localized in bacterial genomes with other carbohydrate metabolism genes, which points to a significant role of singleton genes. Co-localized genes form cassettes, ranging in size from two to fifteen genes.

SUBMITTER: Kaznadzey A 

PROVIDER: S-EPMC5702140 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature