Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.

ABSTRACT:

Background

Genome-wide association studies are useful for discovering genotype-phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-coding variation as well as variation in expression to be combined into "gene level" effects.

Methods

Previous work has shown that warfarin dose can be predicted using information from genetic variation that affects protein-coding regions. Here, we introduce a method that improves dose prediction by integrating tissue-specific gene expression. In particular, we use drug pathways and expression quantitative trait loci knowledge to impute gene expression-on the assumption that differe

SUBMITTER: Gottlieb A 

PROVIDER: S-EPMC5702158 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature