Efficacy and safety of tiotropium and olodaterol in COPD: a systematic review and meta-analysis.

ABSTRACT:

Background

Long-acting bronchodilators are the cornerstone of pharmacologic treatment of COPD. The new combination of long-acting muscarinic antagonist (LAMA) tiotropium (TIO) and long acting beta-agonists (LABA) olodaterol (OLO) has been introduced as fist line therapy for COPD. This article analyses the evidence of efficacy and safety of the TIO/OLO combination.

Methods

A systematic review and metaanalysis of randomized controlled trials (RCT) with a period of treatment of at least 6 weeks, in patients with COPD confirmed by spirometry, comparing combined treatment with TIO/OLO (approved doses only), with any of the mono-components or any other active comparator administered as an inhalator.

Results

A total of 10 Randomized controlled trials (RCT) were identified (N

SUBMITTER: Miravitlles M 

PROVIDER: S-EPMC5702233 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature