MitoCore: a curated constraint-based model for simulating human central metabolism.

ABSTRACT:

Background

The complexity of metabolic networks can make the origin and impact of changes in central metabolism occurring during diseases difficult to understand. Computer simulations can help unravel this complexity, and progress has advanced in genome-scale metabolic models. However, many models produce unrealistic results when challenged to simulate abnormal metabolism as they include incorrect specification and localisation of reactions and transport steps, incorrect reaction parameters, and confounding of prosthetic groups and free metabolites in reactions. Other common drawbacks are due to their scale, making them difficult to parameterise and simulation results hard to interpret. Therefore, it remains important to develop smaller, manually curated models.

Results

We p

SUBMITTER: Smith AC 

PROVIDER: S-EPMC5702245 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature