Computational Modeling of Micrometastatic Breast Cancer Radiation Dose Response.

ABSTRACT:

Purpose

Prophylactic cranial irradiation (PCI) involves giving radiation to the entire brain with the goals of reducing the incidence of brain metastasis and improving overall survival. Experimentally, we have demonstrated that PCI prevents brain metastases in a breast cancer mouse model. We developed a computational model to expand on and aid in the interpretation of our experimental results.

Methods and materials

MATLAB was used to develop a computational model of brain metastasis and PCI in mice. Model input parameters were optimized such that the model output would match the experimental number of metastases per mouse from the unirradiated group. An independent in vivo-limiting dilution experiment was performed to validate the model. The effect of whole brain irradiation

SUBMITTER: Smith DL 

PROVIDER: S-EPMC5702256 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature