Metabolomic analysis of insulin resistance across different mouse strains and diets.

ABSTRACT: Insulin resistance is a major risk factor for many diseases. However, its underlying mechanism remains unclear in part because it is triggered by a complex relationship between multiple factors, including genes and the environment. Here, we used metabolomics combined with computational methods to identify factors that classified insulin resistance across individual mice derived from three different mouse strains fed two different diets. Three inbred ILSXISS strains were fed high-fat or chow diets and subjected to metabolic phenotyping and metabolomics analysis of skeletal muscle. There was significant metabolic heterogeneity between strains, diets, and individual animals. Distinct metabolites were changed with insulin resistance, diet, and between strains. Computational analysis revealed 1

SUBMITTER: Stockli J 

PROVIDER: S-EPMC5702658 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature