A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.

ABSTRACT:

Background

The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear.

Methods

We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships.

Results

We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, indepen

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC5702961 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature