Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial.

ABSTRACT:

Importance

Iron deficiency is present in approximately 50% of patients with heart failure with reduced left ventricular ejection fraction (HFrEF) and is an independent predictor of reduced functional capacity and mortality. However, the efficacy of inexpensive readily available oral iron supplementation in heart failure is unknown.

Objective

To test whether therapy with oral iron improves peak exercise capacity in patients with HFrEF and iron deficiency.

Design, setting, and participants

Phase 2, double-blind, placebo-controlled randomized clinical trial of patients with HFrEF (<40%) and iron deficiency, defined as a serum ferritin level of 15 to 100 ng/mL or a serum ferritin level of 101 to 299 ng/mL with transferrin saturation of less than 20%. Participants were enr

SUBMITTER: Lewis GD 

PROVIDER: S-EPMC5703044 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature