Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage.

ABSTRACT: Osteoarthrosis is a debilitating disease affecting millions, yet engineering materials for cartilage regeneration has proven difficult because of the complex microstructure of this tissue. Articular cartilage, like many biological tissues, produces a time-dependent response to mechanical load that is critical to cell's physiological function in part due to solid and fluid phase interactions and property variations across multiple length scales. Recreating the time-dependent strain and fluid flow may be critical for successfully engineering replacement tissues but thus far has largely been neglected. Here, microindentation is used to accomplish three objectives: (1) quantify a material's time-dependent mechanical response, (2) map material properties at a cellular relevant length scale thro

SUBMITTER: Wahlquist JA 

PROVIDER: S-EPMC5703066 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature