Use of beta-blockers and risk of serious upper gastrointestinal bleeding: a population-based case-control study.

ABSTRACT:

Background

Some studies indicate a reduced risk of serious upper gastrointestinal bleeding (UGIB) for users of beta-blockers, but the association remains to be confirmed in larger studies and characterized with respect to differences among beta-blockers. We aimed to assess whether beta-blocker use decreases the risk of UGIB.

Methods

We conducted a register-based, population-based case-control study in Denmark. We identified cases with a first validated discharge diagnosis of UGIB during the period 1995-2006. Controls were selected by risk-set sampling in a ratio of 10:1. We estimated crude and adjusted odds ratios (ORs) of the association between current beta-blocker use and the risk of UGIB by using conditional logistic regression and further stratified by selective and non

SUBMITTER: Reilev M 

PROVIDER: S-EPMC5703107 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature