Development and in vitro evaluations of new decitabine nanocarriers for the treatment of acute myeloid leukemia.

ABSTRACT: Decitabine is a hydrophilic drug that acts by hypomethylating DNA. Decitabine is used in Europe for the treatment of acute myeloid leukemia (AML) in patients aged ≥65 years. However, it can only be administered intravenously due to very low oral bioavailability and a large distribution volume. Oral administration would allow outpatient treatment, improving quality of life and reducing treatment costs. The present study proposes to develop lipid nanocapsules (LNCs), originally designed for lipophilic drugs, to encapsulate decitabine. Two different formulations of LNCs were designed: LNCs based on a high proportion of Transcutol^® HP (THP-LNCs) and LNCs associated with a mixture of Transcutol^® HP and Tween^® 80 (THP-T80-LNCs). The second formulation had a diame

SUBMITTER: Briot T 

PROVIDER: S-EPMC5703174 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature