Highly scalable multichannel mesh electronics for stable chronic brain electrophysiology.

ABSTRACT: Implantable electrical probes have led to advances in neuroscience, brain-machine interfaces, and treatment of neurological diseases, yet they remain limited in several key aspects. Ideally, an electrical probe should be capable of recording from large numbers of neurons across multiple local circuits and, importantly, allow stable tracking of the evolution of these neurons over the entire course of study. Silicon probes based on microfabrication can yield large-scale, high-density recording but face challenges of chronic gliosis and instability due to mechanical and structural mismatch with the brain. Ultraflexible mesh electronics, on the other hand, have demonstrated negligible chronic immune response and stable long-term brain monitoring at single-neuron level, although, to date, it ha

SUBMITTER: Fu TM 

PROVIDER: S-EPMC5703340 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature