Anti-TB drug concentrations and drug-associated toxicities among TB/HIV-coinfected patients.

ABSTRACT:

Background

Toxicities due to anti-TB treatment frequently occur among TB/HIV-coinfected patients.

Objectives

To determine the association between anti-TB drug concentrations and the occurrence of hepatotoxicity and peripheral neuropathy among TB/HIV-coinfected patients.

Methods

TB/HIV-coinfected patients were started on standard dose anti-TB treatment according to WHO guidelines. Anti-TB drug concentrations were measured using HPLC 1, 2 and 4 h after drug intake at 2, 8 and 24 weeks following initiation of TB treatment. Participants were assessed for hepatotoxicity using Division of AIDS toxicity tables and for peripheral neuropathy using clinical assessment of tendon reflexes, vibration sensation or symptoms. Cox regression was used to determine the association betwe

SUBMITTER: Sekaggya-Wiltshire C 

PROVIDER: S-EPMC5703350 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature