Human Genomics of Mycobacterium tuberculosis Infection and Disease.

ABSTRACT:

Purpose of review

The study of the genetic basis of tuberculosis pathogenesis has benefited from powerful technological innovations, a more structured definition of latent and clinical manifestations of the disease, and the application of functional genomics approaches. This short review aims to summarize recent advances and to provide a link with results of previous human genetic studies of tuberculosis susceptibility.

Recent findings

Transcriptomics has been shown to be a useful tool to predict progression from latency to clinical disease while functional genomics has traced the molecular events that link pathogen-triggered gene expression and host genetics. Resistance to infection with Mycobacterium tuberculosis has been revealed to be strongly impacted by host gen

SUBMITTER: Orlova M 

PROVIDER: S-EPMC5703416 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature