The effect of micronutrient supplementation on active TB incidence early in HIV infection in Botswana.

ABSTRACT:

Background

Coinfection with active tuberculosis (TB) is one of the leading causes of death in people living with HIV (PLWH) in Africa. This investigation explores the role of micronutrient supplementation in preventing active TB in PLWH.

Methods

A randomized trial of nutritional supplementation was conducted among antiretroviral- naïve (without previous antiretroviral treatment [ART]) HIV-infected people in Botswana between 2004 and 2009. The study had a factorial design with four arms: the selenium (Se) alone arm, the multivitamins (MVT) alone arm that contained vitamin B complex and vitamins C and E, the combined Se+MVT group and the placebo group. Those participants with prior or current active TB were excluded, as were participants with advanced HIV disease (CD4 <250 cel

SUBMITTER: Campa A 

PROVIDER: S-EPMC5703420 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature