Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients.

ABSTRACT: Paraoxonase-1 (PON1) is an intra-cellular antioxidant enzyme found also in the circulation associated with high-density lipoproteins. The activity of this enzyme has been shown to be decreased in breast cancer (BC) patients. The aims of our study were to investigate the changes produced by radiotherapy (RT) on activity and concentration of serum PON1 in BC patients, and to evaluate the observed variations in relation to clinical and pathological characteristics of patients and tumors, and the response to treatment. We studied 200 women with BC who were scheduled to receive RT following excision of the tumor. Blood for analyses was obtained before and after the irradiation procedure. The control group was composed of 200 healthy women. Relative to control, BC patients had significantly lowe

SUBMITTER: Arenas M 

PROVIDER: S-EPMC5703554 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature