Development and validation of an immunoperoxidase antigen detection test for improved diagnosis of rabies in Indonesia.

ABSTRACT: Rabies continues to pose a significant threat to human and animal health in regions of Indonesia. Indonesia has an extensive network of veterinary diagnostic laboratories and the 8 National laboratories are equipped to undertake diagnostic testing for rabies using the commercially-procured direct fluorescent antibody test (FAT), which is considered the reference (gold standard) test. However, many of the Indonesian Provincial diagnostic laboratories do not have a fluorescence microscope required to undertake the FAT. Instead, certain Provincial laboratories continue to screen samples using a chemical stain-based test (Seller's stain test, SST). This test has low diagnostic sensitivity, with negative SST-tested samples being forwarded to the nearest National laboratory resulting in signific

SUBMITTER: Rahmadane I 

PROVIDER: S-EPMC5703572 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature